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Xalira Assay

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Rack sheet · PDE5 rack

Three oral PDE5 clocks compared, no shop ranking

Last reviewed · 10 min read · Updated

Cialis 2.5-20, Viagra 25-50, and Levitra 5-20 on one rack

Specimen card

OnsetSildenafil and vardenafil: often 30-60 min fasting. Tadalafil: from ~30 min, peak ~2 h
DurationTadalafil up to 36 h vs placebo. Sildenafil and vardenafil about 4-5 h
FoodTadalafil: no food effect. Sildenafil: Tmax +60 min, Cmax -29%. Vardenafil: Cmax -18-50%
AlcoholAll three vasodilate; Cialis label names 5 units as the orthostatic example

Healthline-style 2026 titles still ask which ED tablet is best. This rack answers with three clocks and three locked rungs: tadalafil 2.5-20 mg, sildenafil 25-50 mg (100 mg as step-up talk), vardenafil 5-20 mg. No league table. No invented dollar.

Shared ban: nitrates and riociguat. Shared need: sexual stimulation. Different meals, different half-lives, one QT screen. Jonas Berg reviewed the sheet on 21 August 2026.

Best Cialis vs Viagra vs Levitra compared 2026

Healthline still pairs Cialis, Viagra, and Levitra in one 2026 headline, then hands the reader a winner. Mannerheimintie files the same three INNs and refuses the trophy. Efficacy in the class is close enough that duration, food, daily versus as-needed, and a QT screen decide the visit. A shop ranking does not.

The locked rungs on this rack match the specimens: tadalafil 2.5 mg daily through 20 mg as needed; sildenafil 25 and 50 mg, with 100 mg only as a step-up sentence; vardenafil 5-20 mg film, with 2.5 mg reserved for CYP cuts. Those locks are editorial SERP choices so each page stops pretending one pretty milligram is the whole label.

Read a single INN when the question is one tablet. Stay on this sheet when the question is which clock belongs in the house. The tadalafil specimen, the sildenafil specimen, and the vardenafil specimen hold the trial numbers this rack will not reprint in full.

Shared nitrate ban, different CYP cuts

Organic nitrates and nitrites, regular or intermittent, are contraindicated with all three. Riociguat is the same kind of ban. Poppers sit in that family. The half-life difference changes how long the nitrate conversation lasts - tadalafil's 17.5 hours is not sildenafil's 4 - but it does not change the ban.

CYP3A4 is shared; the caps are not. Tadalafil with a strong inhibitor: 10 mg as needed no more than every 72 hours, or 2.5 mg daily. Sildenafil with ritonavir: 25 mg once in 48 hours. Vardenafil with ritonavir: 2.5 mg once in 72 hours after a 49-fold AUC jump. Do not translate one cap onto another tablet.

Vardenafil adds the QT avoid: congenital long QT, or Class IA (quinidine, procainamide) or Class III (amiodarone, sotalol) antiarrhythmics. The QT log holds the 59-man study. If that line is live on the chart, this rack's vardenafil column closes and the other two columns stay open for the clinician.

What 2026 best-pill titles still skip

They skip the 24-hour nitrate unknown after sildenafil, the 17.5-hour nitrate conversation after tadalafil, and the vardenafil QT avoid. They skip Revatio and Adcirca as stacking traps. They skip Staxyn as a non-swap. They skip the 49-fold ritonavir jump on vardenafil and the 25 mg in 48 hours cap on sildenafil.

They also skip the trial populations. Vardenafil's diabetes and post-prostatectomy SEP3 rates sit well below the general-ED 65% on 20 mg. Sildenafil's 21-trial program still showed benefit across organic, psychogenic, and mixed ED, including 70% versus 29% intercourse success in two diary studies. Tadalafil's 36-hour claim is versus placebo, not versus a head-to-head trophy this rack will invent.

Back pain 12-24 hours after tadalafil, blue-green hue-test changes after high-dose sildenafil, and rhinitis on vardenafil are ordinary labelled reactions. A title that treats one INN as side-effect-free is selling a ribbon. Mannerheimintie files the reactions next to the clocks.

Avanafil (Stendra) can start working in 15-45 minutes on other 2026 lists. It is not on this rack. Adding a fourth clock to win a search phrase would be a different sheet. This page is Cialis 2.5-20, Viagra 25-50, Levitra 5-20.

Jonas will also skip invented cash leagues. Each specimen has a sourced US board for its locked rungs. This rack will not print a three-way price trophy. GoodRx stays in those captions. A Helsinki street price will not be invented so a 2026 title can say cheap.

If the reader only wanted a winner chip, they wanted a different kind of page. Mannerheimintie files clocks, locks, and bans. The visit still picks the tablet.

Which rung this desk locks for each INN

Tadalafil: daily ED starts at 2.5 mg and may rise to 5 mg. As-needed starts at 10 mg and may go to 20 mg or down to 5 mg. Five milligrams daily also carries BPH and ED-plus-BPH. Do not stack daily and as-needed on the same day. Do not treat a 20 mg weekend tablet as prostate therapy.

Sildenafil: 50 mg is the labelled start for most men, 30 minutes to 4 hours before activity. Twenty-five milligrams is the cut for age 65, hepatic impairment, CrCl under 30 mL/min, alpha-blockers, and strong CYP3A4 inhibitors. One hundred milligrams is the maximum after effect and toleration - named on this rack, not locked as a first Helsinki pull.

Vardenafil film: 10 mg start about 60 minutes before, then 5 or 20 mg. Age 65 and Child-Pugh B start at 5 mg; Child-Pugh B tops at 10 mg. Two-point-five milligrams is a ritonavir and strong-CYP tablet (once in 72 hours with ritonavir), not the SERP floor. Staxyn 10 mg ODT is a different formulation and is not on this film rack.

Rung mistakes 2026 titles still make

  • Tadalafil 20 mg is a ceiling, not a 2026 default
  • Sildenafil 100 mg is a step-up after 50 mg on a clean evening
  • Vardenafil 2.5 mg is a CYP-cut, not a cute starter
  • None of the three is once-plus-once the same night

Who the 2026 compare actually helps

Daily tadalafil helps the household that hates a countdown. As-needed tadalafil 10-20 mg helps the household that wants two evenings without a second swallow. Sildenafil 25-50 mg helps the household that wants a short, dated window and can keep a fatty dinner from landing on the peak. Vardenafil 5-20 mg helps when the chart is clear of QT drugs and someone still wants a short-acting film with a different adverse-effect mix.

Diabetes and post-prostatectomy lower the absolute success rates for vardenafil in the labelled special-population trials. Sildenafil's 21-trial program still showed benefit across organic and psychogenic and mixed ED. Tadalafil's 36-hour as-needed claim is versus placebo, not versus the other two INNs in a head-to-head trophy trial this sheet will invent.

Avanafil exists and is not on this rack. Export sildenafil brands sit on other Xalira specimens. This page is three US oral ED labels in 2026 language. If a title promised a shop ranking, it promised something Mannerheimintie does not print.

Three clocks, not three scores

Tadalafil's mean half-life is 17.5 hours. As-needed use improved erectile function versus placebo out to 36 hours. Daily 2.5 or 5 mg exists because that half-life can hold a floor. Sildenafil's half-life is about 4 hours; RigiScan effect is still there at 4 hours and weaker than at 2. Vardenafil's half-life is about 4-5 hours, with a median Tmax of 60 minutes and bioavailability of only about 15%.

A 2026 title that treats 36 hours as a higher score has already left the clinic. Some couples want a short, dated window. Some want Saturday and Sunday on one swallow. Some want a small daily tablet and no calendar. Those are three different bests. This rack will not collapse them.

Onset marketing is the other false score. Tadalafil can be felt near 30 minutes and still peak near 2 hours (range 0.5-6). Sildenafil's fasted median Tmax is 60 minutes (30-120). Vardenafil's median is also 60 minutes. 'Fastest pill' is a comment-thread sport. Median peaks on this bench look alike for the two short-acting drugs.

Helsinki 2026 rack locks. Not a shop ranking.
INN (brand)Locked rungsClock this rack will defend
Tadalafil (Cialis)2.5-20 mg full ladderDaily floor or 36-hour window; food quiet
Sildenafil (Viagra)25-50 mg; 100 mg step-up onlySingle evening; dinner moves the peak
Vardenafil (Levitra)5-20 mg filmSingle evening; QT screen; fat cuts Cmax 18-50%

Food and alcohol on one bench

Tadalafil may be taken without regard to food. That sentence is why dinner compares keep handing Cialis the easy win. Sildenafil with a high-fat meal: Tmax delayed about 60 minutes, Cmax cut about 29%. Vardenafil with a high-fat meal: Cmax cut 18-50% across two food-effect studies. A steak does not disqualify the short-acting drugs. It changes when you judge them.

Alcohol is a class vasodilator problem. The Cialis label is the one that names a number: 5 units or more can add orthostatic signs with the tablet. Sildenafil and vardenafil do not get a free pass because their labels are less numeric. Standing dizziness after any of the three plus a long dinner is a sit-down problem, not a cue for a second tablet.

The sildenafil meal log and the tadalafil weekend assay keep those pairs on dated notes. This sheet only needs the compare: food is a tadalafil advantage, not a moral ranking, and alcohol is shared risk with one labelled example.

Read the specimen, not a winner chip

Best, on this rack, is a clock plus a lock plus a visit. Cialis 2.5-20, Viagra 25-50, Levitra 5-20. Food, QT, nitrates, and CYP caps do the rest. Jonas Berg, Mannerheimintie 18. Mail [email protected] if a row is wrong. Do not ask this sheet to name a champion.

Open the dated logs when the question is narrower: weekend tadalafil, daily versus 20 mg, sildenafil after dinner, sildenafil 25 versus 50, vardenafil QT, vardenafil onset. The rack is the map. The specimen is the assay.

Sources

  1. DailyMed CIALIS - 2.5-20 mg, 36-hour window, food, 5-unit alcohol example.
  2. DailyMed VIAGRA - 25/50/100 mg, meal delay, 4-hour window.
  3. DailyMed LEVITRA - 5-20 mg film, QT study, food Cmax cut.
  4. Healthline Cialis vs Viagra vs Levitra - 2026 title shape this rack answers without a shop rank.

Checked against the current label and reviewed by Dr. Jonas Berg. See Sample, Assay, Peer-stamp, Publish.

Specimen thread

Helsinki readers who arrived on a best-Cialis-versus-Viagra-versus-Levitra 2026 title. This thread will not name a winner.

Riikka, Töölö Just tell me which of the three is best in 2026.

Desk reply

I will not. Best is a clock. Tadalafil if you want a daily floor or a window out to 36 hours and you can live with the longer nitrate conversation. Sildenafil if you want a single evening and you can keep a fatty dinner off the peak. Vardenafil if the QT line is clear and you still want a short-acting film. A 2026 headline that crowns one INN is doing a shop's job. This rack does Mannerheimintie's job: three locked rungs and the bans that outrank the headline. Open the specimen for the INN you are actually holding.

Oskari, Espoo Is 100 mg Viagra the best if we only get one try this month?

Desk reply

No. Fifty milligrams is the labelled start for most men. One hundred milligrams is a step-up after effect and toleration. A one-try-this-month story is how 100 mg gets oversold in 2026 comment threads. If the one try meets a fatty dinner, you may have assayed the meal. The dose-rack log keeps 25 versus 50 as the first fork. This rack will not move 100 mg into the locked first rungs because the month is short.

Markus, Kallio He takes ritonavir. Which column even stays open?

Desk reply

All three stay theoretically open with brutal caps, and none stay open as a 2026 default tablet. Tadalafil: 10 mg as needed every 72 hours or 2.5 mg daily. Sildenafil: 25 mg once in 48 hours. Vardenafil: 2.5 mg once in 72 hours after a 49-fold AUC jump. I will not pick the remaining column from Mannerheimintie. The clinician who wrote the ritonavir does. If a title offered 20 mg Cialis or 50 mg Viagra as 'best' on that chart, the title was wrong.

Jari, Vuosaari We hate planning. Is daily Cialis automatically the answer?

Desk reply

It is the labelled tool for a floor without a countdown: 2.5 mg daily, then 5 mg if needed. It is not automatic if nitrates might be needed, if a strong CYP3A4 inhibitor is on the list, or if someone wanted a 20 mg weekend tablet and called it daily. Do not swallow daily tadalafil and an as-needed extra on the same day. The daily sample log keeps 2.5 versus 20 on one page. Hating a plan is a real preference. It is not a reason to skip the nitrate question.

Pinja, Lauttasaari Can this sheet tell us which pharmacy is cheapest?

Desk reply

No. Each specimen has a sourced US cash block for its locked rungs. This rack does not invent a three-way price league. GoodRx stays in those captions. Costco, Wegmans, H-E-B, and Giant Food are the pharmacy pages we link. Xalira does not dispense. [email protected] is for a broken row, not a cart. Finnish filling stays with a Finnish prescriber. If you wanted a shop ranking, you wanted a different kind of page than this catalogue prints.

Helmi, Kamppi He is on amiodarone. Which column closes?

Desk reply

The vardenafil column. Class III drugs such as amiodarone are a labelled avoid for Levitra. Class IA drugs and congenital long QT sit on the same avoid. Sildenafil and tadalafil still have their own nitrate and CYP rules, but they do not carry this QT avoid at the same length. I will not pick the remaining column by email. The clinician who owns the arrhythmia chart picks it. The QT log is the page to read before anyone tries a 'low Levitra dose' workaround.

Seija, Arabianranta Where do I go next if I already know we want the long clock?

Desk reply

The tadalafil specimen, then either the weekend assay if the tablet is 10-20 mg as needed or the daily sample if the bottle is 2.5-5 mg. Bring nitrates, creatinine, and the CYP list to the visit. If you only thought you wanted the long clock because a 2026 title said Cialis is best, read the three-clock section again. A short window is not a lesser drug. It is a different evening.